Evidence map›Paper›PMID 41909124›Full record

ArticleFrontiers in cell and developmental biology2026

Gatm ablation disrupts spermatogenesis by impairing ribosome biogenesis and coupling defective steroid biosynthesis to immunoglobulin silencing.

Shun Li, Lixiang Chen, Mengmin Zhu, Lin Yang, Hanqing Wu, Xiaohui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shun Li *Department of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lixiang Chen *Department of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Mengmin ZhuDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lin YangSchool of Life Sciences, Shanghai Normal University, Shanghai, China.
Hanqing WuSchool of Life Sciences, Shanghai Normal University, Shanghai, China.
Xiaohui ZhouDepartment of Animal Model, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glycine amidinotransferase (GATM) catalyzes the rate-limiting step in creatine biosynthesis, a pathway essential for cellular energy buffering in tissues with high metabolic demands. While its roles in muscle and brain are well established, the function of GATM in testicular development and spermatogenesis remains largely unexplored. Methods: We generated a constitutive Results: Conclusion: Our findings establish GATM as a multifunctional regulator of spermatogenesis, integrating creatine-dependent energy metabolism with translational capacity, organelle architecture, and immune-related gene regulation. The coordinated disruption of mitochondrial and ribosomal pathways provides a novel mechanistic framework for understanding the metabolic origins of male infertility.

Indexed as

cacospermiacreatine metabolismGATMimmunoglobulin silencingmale infertilityribosome biogenesisspermatogenesistesticular transcriptome

Identifiers

PMID41909124
PMCPMC13017889

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.