ReviewBiochemistry and biophysics reports2026
Regulation of epidermal growth factor receptors: The role of c-Cbl, Cdc42, and miRNAs in breast cancer.
Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- WISP-3 promotes tumor-monocyte adhesion through a MEK/ERK-dependent miR-12131/ICAM-4 axis in lung adenocarcinoma.International journal of medical sciences · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer, a global health issue, is marked by increasing prevalence and diverse molecular subtypes, which complicate effective treatment strategies. A relevant aspect in breast cancer etiology and development is epidermal growth factor receptor (EGFR) dysregulation. This review examines the intricate regulation of EGFR, focusing on the roles of signaling molecules and microRNAs (miRNAs) in EGFR regulation in breast cancer. The paper delves into the molecular mechanisms underlying EGFR dimerization, activation, and downstream routes for signaling, emphasizing the roles of signaling molecules such as Cbl and Cdc42. Furthermore, the emerging role of miRNAs as essential modulators of gene activity in breast cancer is discussed, focusing on differential expression patterns and functional implications in tumor progression. By elucidating the regulatory networks involving EGFR, signaling molecules, and miRNAs, the current review offers insights into potential therapeutic targets and avenues for future research in breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.