Successful GH Treatment of Hepatopulmonary Syndrome in Panhypopituitarism-related Advanced Liver Disease.

Stephanie Chen, Rodrigo Diaz-Lankenau, Allison Kwong, Julia Chang, James McAvoy, Yu Kuang Lai

Abstract readCase Reports

In one paragraph

Article in JCEM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Stephanie ChenDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0009-0008-3850-6222

Rodrigo Diaz-LankenauDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.

Allison KwongDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305, USA.

Julia ChangDivision of Endocrinology, Gerontology, & Metabolism, Stanford University, Stanford, CA 94305, USA.

James McAvoyDivision of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA 94305, USA.

Yu Kuang LaiDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatopulmonary syndrome (HPS) is a known pulmonary vascular complication of chronic liver disease. In rare circumstances, HPS has been described in the context of panhypopituitarism. An underlying mechanism of panhypopituitarism-related liver injury is thought to stem from GH deficiency, leading to steatohepatitis from augmented lipid deposition within hepatocytes. Although liver transplantation remains the definitive treatment for HPS, resolution of panhypopituitarism-related HPS following GH replacement therapy has been occasionally described. These successful cases uniformly showed hepatic steatosis on biopsy that resolved after GH replacement, suggesting GH may effectively reverse the pathological process before permanent damage occurs. We present the first reported case of panhypopituitarism-related HPS successfully treated with GH replacement in the presence of significant liver fibrosis without steatosis. This case highlights the sustained therapeutic efficacy of GH even in advanced liver disease and adds to the limited literature regarding successful treatment of HPS, especially in the context of panhypopituitarism, without liver transplantation.

Indexed as

case reportgrowth hormonehepatopulmonary syndromepanhypopituitarism

Identifiers

PMID41909159

DOI10.1210/jcemcr/luaf307

PMCPMC13019524

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.