Role of gut microbiota metabolites in maintaining intestinal health and preventing weaning-associated diarrhea in piglets.

Wenpeng Wu, Shuyue Wang, Chenyu Xue, Na Dong

Abstract readReview

In one paragraph

Review in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The gut-brain-gonad axis mediates salinity adaptation in an invasive turtle: causal evidence from microbiota transplantation and metabolite supplementation.Animal microbiome · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenpeng WuLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.

Shuyue WangLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.

Chenyu XueLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.

Na DongLaboratory of Molecular Nutrition and Immunity, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Weaning is a critical challenge in swine production. Early weaning induces stress in piglets, which compromises intestinal barrier function, disrupts gut microbial homeostasis, and results in diarrhea. Enhancing intestinal microbial homeostasis by modulating the gut microbiota composition is considered an effective strategy to alleviate weaning-related diarrhea in piglets. However, due to the high degree of microbial crosstalk, directly investigating host-microbiota interactions remains challenging. Gut microbial metabolites, as functional outputs of host-microbiota co-metabolic networks, play pivotal roles in maintaining intestinal barrier integrity and homeostasis by regulating the intestinal epithelial barrier, immune equilibrium, and microbial community interactions. This review comprehensively examines the critical functions and recent advancements in understanding four major classes of microbial metabolites-short-chain fatty acids, amino acid derivatives, secondary bile acids, and vitamins-in safeguarding intestinal barrier integrity and preventing diarrhea during the weaning transition. By synthesizing current evidence, this review highlight how targeting gut microbial metabolites offers novel therapeutic avenues to overcome the limitations of direct microbiota modulation, thereby preserving intestinal homeostasis and preventing weaning-associated diarrhea in piglets.

Indexed as

Gut microbiota metaboliteIntestinal barrierWeaning-associated diarrhea

Identifiers

PMID41909174

DOI10.1016/j.aninu.2025.10.004

PMCPMC13019811

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.