ReviewJournal of hepatocellular carcinoma2026
Exosome-Mediated Regulation of Aerobic Glycolysis in Hepatocellular Carcinoma: Mechanisms and Therapeutic Implications.
Review in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is one of the most common and poor prognosis digestive malignant tumors with high morbidity and mortality worldwide. Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancer metabolism and plays a pivotal role in the genesis, development, metastasis and drug resistance of HCC. Exosomes are nanoscale membrane vesicles secreted by cells and widely found in various body fluids, capable of carrying a variety of bioactive molecules, such as proteins, nucleic acids, lipids, etc, and mediating intercellular communication. Increasing evidence indicates that exosomes regulate metabolic reprogramming in HCC by transferring specific bioactive molecules or modulating key signaling pathways. Through these mechanisms, exosomes influence the expression and activity of glycolysis-related enzymes, ultimately affecting the proliferation, invasion, migration, and chemosensitivity of HCC cells. This review focuses on the exosome-mediated regulation of aerobic glycolysis in HCC and highlights the therapeutic potential of targeting exosome-mediated metabolic pathways, offering new perspectives for combination treatment strategies in HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.