ArticleCancer management and research2026
Addressing the Neglected Burden of Cancer Cachexia: A Quasi-Experimental Study at Uganda Cancer Institute.
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Cancer cachexia is a debilitating syndrome contributing to significant morbidity and mortality. Despite its impact on survival and quality of life, it remains under-recognized and undertreated, particularly in low- and middle-income countries (LMICs) where structured care models are scarce. Objective: This study evaluated impact of a structured educational intervention on patient knowledge, emotional coping, and practice outcomes at Uganda Cancer Institute (UCI). Methods: A longitudinal quasi experimental with a pre and post study design was used to enroll 484 patients with cancer cachexia. The intervention consisted of structured educational sessions delivered in-person and via SMS, and data were collected using a questionnaire aligned with international cachexia tools and guidelines. Analysis was performed in STATA (v18) with descriptive statistics. Results: Awareness of cancer cachexia increased to 94.2% following the intervention. Improvements were noted in nutrition-impacting symptoms and emotional well-being including reductions in eating-related distress (15-25%), family conflict (14-17%) and body image concerns (23-29%). In contrast, declines were observed in coping ability (37%), self-rated health (42%), and quality of life (35%) reflecting awareness paradox. While weight-loss and sarcopenia improved (9-13%), physical strength and activity levels decreased (6-8%) due to disease progression reflected in a higher proportion of patients with worsened ECOG and advanced malignancies (61.7%). Conclusion: Tailored interventions can enhance awareness and self-care in cancer cachexia, even in LMICs. Sustainable impact requires early detection and integration into multimodal care with institutional support.
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