ReviewFrontiers in cellular neuroscience2026
Function of the large intestine and its interaction with the brain after ischemic stroke: a comprehensive literature review.
Review in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microbiota-innate immune crosstalk drives atherosclerosis: mechanisms, disease progression, and emerging therapeutic strategies.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The large intestine, part of the distal gastrointestinal tract, is vital for water and electrolyte absorption and microbial fermentation. It is also a significant immune organ endowed with an extensive and intricate neural network. Intestinal epithelial cells are essential for endocrine regulation and maintaining the integrity of the intestinal barrier. Stroke, a leading cause of adult mortality and disability, occurs when there is a lack of oxygen to the brain and involves complex cerebrovascular dynamics that significantly impact systemic functions. In this framework, the gut-brain axis-the bidirectional circuitry connecting the gut and the central nervous system (CNS)-emerges as a critical interface. This review examines the immunological, neurological, endocrine, and barrier functions of the large intestine and explores its interplay with stroke pathophysiology. By detailing the interrelation between stroke and large intestinal functions, this paper aims to provide a foundational reference for advancing research into their intertwined mechanisms and identifying potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.