Evidence map›Paper›PMID 41909509›Full record

ReviewBioactive materials2026

Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment.

Shanshan Zhang, Rangrang Fan, Haifeng Chen, Hanlin Gong, Min Mu, Bo Han, Gang Guo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shanshan ZhangDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Rangrang FanDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Haifeng ChenDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hanlin GongDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Min MuDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bo HanSchool of Pharmacy, Institute for Safflower Industry Research, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of Education, Shihezi University, Shihezi, 832002, China.
Gang GuoDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity treatment is entering a new era with the advent of multifunctional nanomaterials capable of precise biological intervention. This review highlights their pivotal role in overcoming key therapeutic limitations, including poor targeting, systemic toxicity, and low bioavailability. Based on the systematic analysis of lipid metabolism, we propose five strategic intervention points: reducing lipid intake, interfering with absorption, inhibiting storage, promoting consumption, and remodeling the adipose tissue microenvironment. Furthermore, we examine the application of diverse nanoplatforms in these therapeutic strategies, ranging from inorganic or polymeric nanoparticles to natural biopolymer-based nanomedicine, and demonstrate their potential in realizing precise targeting and transdermal drug delivery. By integrating mechanistic insights with advanced nanomaterial design, this work not only outlines a systematic framework for obesity nanomedicine, but also accelerates the translational path toward precision anti-obesity therapies.

Indexed as

Lipid metabolismNanomaterialsObesity treatmentTargeted delivery

Identifiers

PMID41909509
PMCPMC13019090

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.