Evidence map›Paper›PMID 41909511›Full record

ArticleBioactive materials2026

Three-dimensional niche-like porous structure locoregionally regulating macrophage immunosenescence rejuvenates aged bone repair.

Da-Wang Zhao, Xiangyu Fei, Haoxin Zhai, Yuxuan Zhang, Rui Hu, Huanyu Liu, Shihao Li, Xiangzhen Kong, Yuanqiang Zhang, Zhonghua Zhang and 1 more

Abstract read
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Da-Wang ZhaoDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Xiangyu FeiKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jingshi Road 17923, Jinan, 250061, PR China.
Haoxin ZhaiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Yuxuan ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Rui HuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Huanyu LiuDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, PR China.
Shihao LiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Xiangzhen KongDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Yuanqiang ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.
Zhonghua ZhangKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jingshi Road 17923, Jinan, 250061, PR China.
Lei ChengDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The decreased reconstruction potential of aging bone marrow mesenchymal stem cells (BMMSCs) fails to resist compromised bone healing, and strategies to remodel the regeneration capacity of senescent BMMSCs are urgently needed. A depletion of ARG1

Indexed as

ImmunosenescenceMacrophage rejuvenationOsteointegrationPorous TiVapor phase dealloying

Identifiers

PMID41909511
PMCPMC13022701

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.