Evidence map›Paper›PMID 41909658›Full record

ArticleFrontiers in immunology2026

Therapeutic hepatitis B vaccine employing DNA prime - MVA boost scheme requires additional priming with recombinant HBsAg to elicit an adequate antibody response.

Hélène A Kerth, Martin Kächele, Nikolas Müller, Swati Singh, Margaret Tulessin, Julia Sacherl, Edanur Ates Öz, Jinpeng Su, Romina Bester, Susanne Miko and 6 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hélène A KerthInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Martin KächeleInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Nikolas MüllerInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Swati SinghInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Margaret TulessinInstitute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Julia SacherlInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Edanur Ates ÖzInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Jinpeng SuInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Romina BesterInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Susanne MikoInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Katja SteigerInstitute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Carolin MoglerInstitute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Dirk H BuschGerman Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.
Jochen M WettengelInstitute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Ulrike Protzer *Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.
Anna D Kosinska *Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic vaccines offer hope for a curative treatment of chronic hepatitis B virus (HBV) infection. We developed a therapeutic hepatitis B vaccine,

Indexed as

Hepatitis B, ChronicHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusVaccines, DNAAnimalsAntibody FormationCD8-Positive T-LymphocytesFemaleHepatitis B AntibodiesHumansImmunization, SecondaryMiceVaccinationVaccinia virusHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesVaccines, DNADNA vaccinefunctional cureHBsAg seroconversionHBVhepatitis Btherapeutic vaccineTherVacB

Identifiers

PMID41909658
PMCPMC13017795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.