Evidence map›Paper›PMID 41909739›Full record

ArticleActa pharmaceutica Sinica. B2026

Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling.

Zhenhui Wu, Yihao Wang, Renjie Wang, Rong Gao, Shubei Li, Bodan Tu, Xiubing Yin, Maoxing Li, Wei Zhou, Huanhua Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhenhui WuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330000, China.
Yihao WangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Renjie WangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Rong GaoBeijing Institute of Radiation Medicine, Beijing 100850, China.
Shubei LiBeijing Institute of Radiation Medicine, Beijing 100850, China.
Bodan TuBeijing Institute of Radiation Medicine, Beijing 100850, China.
Xiubing YinBeijing Institute of Radiation Medicine, Beijing 100850, China.
Maoxing LiBeijing Institute of Radiation Medicine, Beijing 100850, China.
Wei ZhouBeijing Institute of Radiation Medicine, Beijing 100850, China.
Huanhua XuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330000, China.
Zhenfeng WuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330000, China.
Zengchun MaBeijing Institute of Radiation Medicine, Beijing 100850, China.
Xianglin TangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Chengrong XiaoBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yue GaoSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypobaric hypoxia-induced lung injury can exacerbate the incidence of plateau pulmonary edema, but relevant pharmacologic measures are relatively limited. Here, we investigate the possible role of paeoniflorin (Pae) in hypobaric hypoxia-induced lung injury. Through

Indexed as

FerroptosisHypobaric hypoxiaLung injuryMEK2–ERK2–SGK1 axisMitochondrial homeostasisMitochondrial permeability transition porePaeoniflorinProteomics

Identifiers

PMID41909739
PMCPMC13031058

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.