A review of recent advances in generative artificial intelligence models for biomolecular sciences.

Generative artificial intelligence (AI) models, a class of AI techniques that learn data distributions to synthesize novel samples, have emerged as impactful tools across scientific disciplines. In recent years, these models have found extensive applications in fields such as natural language processing and biomedical sciences. Despite their growing influence, comprehensive reviews on the application of generative models in biomolecular sciences remain limited. In this review, we provide a systematic overview of recent advances in generative models applied to biomolecular sciences. We discuss several prominent generative architectures, including variational autoencoders, generative adversarial networks, and diffusion models, highlighting their applications in molecular design and bioinformatics. Additionally, we examine how these models contribute to critical challenges such as molecular property prediction and molecular generation. Finally, we discuss key challenges that remain in this field, including model interpretability, scalability, and the need for high-quality molecular datasets. We highlight emerging research directions that aim to overcome these limitations and propose strategies for improving the reliability and applicability of generative models in biomolecular problems. Through this review, our objective is to provide researchers with a comprehensive understanding of the current landscape of generative modeling in biomolecular sciences and to inspire further advancements in this interdisciplinary area.