Evidence mapPaperPMID 41909887Full record

ArticleGut microbes reports2025

Probiotic supplementation improves well-being and anxiety in healthy women: An exploratory, randomized, double-blind, placebo-controlled study.

Daryn R Michael, Niall Coates, Joshua Kerry-Smith, Daniel A John, Eleri Hulme, Lauren Owen, Sue F Plummer

Registry-linked trialAbstract read
In one paragraph

Article in Gut microbes reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06507111 (The Impact of Probiotic Supplementation on the Well-being of Women.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06507111 nacompletednot on this map

The Impact of Probiotic Supplementation on the Well-being of Women.

TypeinterventionalSponsorCultech LtdRan2024 to 2025Enrolled50ConditionsFemale, Healthy AgingArmsLab4P, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daryn R MichaelResearch & Development, Cultech Limited, Port Talbot, UK.ORCID https://orcid.org/0000-0001-8546-1153
Niall CoatesResearch & Development, Cultech Limited, Port Talbot, UK.ORCID https://orcid.org/0009-0001-3287-2095
Joshua Kerry-SmithResearch & Development, Cultech Limited, Port Talbot, UK.
Daniel A JohnResearch & Development, Cultech Limited, Port Talbot, UK.ORCID https://orcid.org/0009-0008-7999-8198
Eleri HulmeResearch & Development, Cultech Limited, Port Talbot, UK.
Lauren OwenHuman Behavioural Neuroscience Laboratory, Department of Psychology, School of Humanities and Social Sciences, Leeds Beckett University, Leeds, UK.ORCID https://orcid.org/0000-0002-2548-1926
Sue F PlummerResearch & Development, Cultech Limited, Port Talbot, UK.ORCID https://orcid.org/0000-0002-3919-6173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota plays an important role in the maintenance of health and well-being throughout the life course but little is known about the impact of these changes on the balance of the microbiota and the well-being of women during their midlife transitional phase. In this exploratory, randomized, double-blind, placebo-controlled study, women (45 to 65 years old) received either a daily dose of probiotics or placebo for 4-months. Measurements of overall well-being included anxiety, depression, quality of life and sleep quality, gastrointestinal discomfort and changes to the fecal microbiota composition(ClinicalTrials.gov: NCT06507111). The women in the probiotic group showed a 40% reduction in anxiety, an 18.5% improvement in quality of life and indications of improved sleep, resulting in a significant 17.5% improvement in overall well-being compared to those in the placebo. Incidence rates of indigestion and stomach pains were reduced and

Indexed as

anxietymicrobiotaProbioticwell-beingwomen

Identifiers

PMID41909887
PMCPMC12940106

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.