Evidence map›Paper›PMID 41909893›Full record

ArticleGut microbes reports2025

Toxic metals impact gut microbiota and metabolic risk in five African-origin populations.

Julianne A Jorgensen, Candice Choo-Kang, Luyu Wang, Lina Issa, Jack A Gilbert, Gertrude Ecklu-Mensah, Amy Luke, Kweku Bedu-Addo, Terrence Forrester, Pascal Bovet and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Julianne A JorgensenDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-9852-0837
Candice Choo-KangPublic Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.ORCID https://orcid.org/0000-0001-9150-1131
Luyu WangDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-9003-0788
Lina IssaDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Jack A GilbertDepartment of Pediatrics, Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-7920-7001
Gertrude Ecklu-MensahDepartment of Pediatrics, Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-1770-3071
Amy LukePublic Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.ORCID https://orcid.org/0000-0001-8484-9439
Kweku Bedu-AddoDepartment of Physiology, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0001-5479-0691
Terrence ForresterSolutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica.ORCID https://orcid.org/0000-0001-7976-8669
Pascal BovetDepartment of Epidemiology and Health Services, University Center for General Medicine and Public Health (Unisanté), Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-0242-4259
Estelle V LambertDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0003-4315-9153
Dale RaeDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2584-6585
Maria ArgosSchool of Public Health, Boston University, Boston, MA, USA.ORCID https://orcid.org/0000-0003-4234-252X
Tanika N KellyDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-7348-4451
Robert M SargisDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-7061-2983
Lara R DugasPublic Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.ORCID https://orcid.org/0000-0002-0692-8585
Yang DaiDepartment of Bioengineering, College of Engineering, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-7638-849X
Brian T LaydenDivision of Endocrinology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0003-2176-5654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Underlying mechanisms by which exposures to toxic metals/metalloids impact obesity and type 2 diabetes (T2DM) risk remain largely unknown. Gut microbiota have been strongly associated with cardiometabolic risk. To assess relationships between high metal exposures, gut dysbiosis, and metabolic dysregulation, we analyzed associations among gut microbiome taxa, dichotomized metal levels (arsenic, lead, mercury, cadmium), clinical measures (BMI, fasting blood glucose, blood pressure), and diagnoses (hypertension, obesity, diabetes) in 178 African-origin adults (52% female, mean age = 43.0 ± 6.4 years) from Ghana, South Africa, Jamaica, Seychelles, and USA. High vs. low lead and arsenic levels had a significant effect on beta diversity (

Indexed as

African-origin populationsCardiometabolic riskGut microbiomeObesityToxic metalsType 2 diabetes

Identifiers

PMID41909893
PMCPMC12940161

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.