ArticleMicrobiology spectrum2026
Synthesis and synergistic antibacterial activity of rafoxanide derivative as a novel drug for potentiating colistin activity.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Antimicrobial resistance poses a significant global public health challenge in the 21st century, with multidrug resistance in gram-negative bacteria being particularly severe. Colistin (COL) is considered the "last-resort" for treating such infections. Still, its efficacy is significantly reduced due to the emergence and prevalence of mobile colistin resistance (MCR)-mediated acquired drug resistance. Based on the synergistic antibacterial mechanism between the anthelmintic rafoxanide (RAF) and COL, we synthesized a novel RAF derivative (named as dikalisuan) through a carboxymethylation method, and its structure was confirmed using
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