ArticleJournal of computer-aided molecular design2026
In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor.
Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
2 authors.
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Abstract
Limonoids are important constituents of Swietenia macrophylla, exhibiting a range of biological activities that influence human health. Swietenia macrophylla, a well-known medicinal plant, is particularly rich in limonoids, which have been reported to exhibit significant therapeutic potential. Given the increasing interest in natural α-glucosidase inhibitors as potential treatments for diabetes mellitus, this study aimed to isolate, characterize, and evaluate the inhibitory potential of a major limonoid from Swietenia macrophylla seeds. Followed by chromatographic separation of the methanol extract, the purified compound was characterized using high-performance liquid chromatography (HPLC), mass spectrometry (MS), and single-crystal X-ray diffraction. The isolated limonoid, identified as swietenolide, exhibited a molecular weight of 486.20 g/mol and was crystallized in the P2
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