Evidence map›Paper›PMID 41911029›Full record

Observational studyClinical journal of the American Society of Nephrology : CJASN2026

Low Dietary Iodine Intake and Sex-Specific Mortality in Kidney Transplant Recipients.

Yvonne van der Veen, Adrian Post, Daan Kremer, Jiasi Hao, Caecilia S E Doorenbos, Tim J Knobbe, Martin H de Borst, Daan J Touw, Casper F M Franssen, Eva Corpeleijn and 2 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02811835 (Renal Sensing of the Acidifying Effect of Sulphur-containing Amino Acids), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02811835 active not recruitingnot on this map

Renal Sensing of the Acidifying Effect of Sulphur-containing Amino Acids: Consequences for the Relation Between Protein Intake and Blood Pressure in Renal Transplant Recipients

Typeobservational_patient_registrySponsorUniversity Medical Center GroningenRan2008 to 2028Enrolled1,007ConditionsTransplantation Infection, Renal Transplant Donor of Left Kidney
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Low Iodine, High Risk? A Patient Perspective.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yvonne van der VeenDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-5203-7169
Adrian PostDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Daan KremerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-0011-115
Jiasi HaoDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-9625-742
Caecilia S E DoorenbosDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8036-520
Tim J KnobbeDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-3246-3192
Martin H de BorstDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-4127-8733
Daan J TouwDepartment of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-1429-4789
Casper F M FranssenDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-1004-9994
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-2974-3305
Coby AnnemaDivision of Nursing Sciences, Department of Health Sciences, University of Groningen, University Medical Center Groningen Groningen, The Netherlands.ORCID 0000-0001-8663-2145
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-3356-6791

Funding

Top Institute Food and Nutrition A-1003
6 · The paper itself

Abstract

key pointsInadequate iodine intake is common among kidney transplant recipients, particularly in women. Among female kidney transplant recipients, inadequate iodine intake and lower urinary iodine excretion were independently associated with higher mortality. These findings suggest that iodine status may represent a modifiable factor influencing long-term outcomes after kidney transplantation.

backgroundLow iodine intake may be a modifiable risk factor for reduced survival among kidney transplant recipients (KTR). Therefore, we performed sex-stratified analyses to examine whether inadequate iodine intake and low 24-hour urinary iodine excretion are associated with increased mortality.

methodsAdult KTR from the TransplantLines Food and Nutrition Biobank and Cohort Study were included and compared with healthy controls. Associations between 24-hour urinary iodine intake (continuous and classified as inadequate <135 ug/d) with mortality were evaluated using multivariable sex-stratified Cox regression analyses.

resultsThe study included 624 KTR (43% female, 53±12 years) and 214 healthy controls (49% female, 58±11 years). Among women, inadequate iodine intake was more common (24% versus 6%; P < 0.001), and urinary iodine excretion was lower (173 [139-231] versus 265 [216-322] μ mol/24 h; P < 0.001) in KTR than controls. Similar findings were observed among men (inadequate intake: 14% versus 6%, P = 0.03; urinary excretion: 211 [161-262] versus 302 [236-361] μ mol/24 h; P < 0.001). During a median follow-up of 5.6 (5.2-6.3) years, 136 (22%) KTR died. The associations of inadequate iodine intake and 24-hour urinary iodine excretion with mortality were modified by sex ( Pinteraction = 0.02; Pinteraction = 0.08), respectively. Among female KTR, inadequate iodine intake (hazard ratio, 3.16 [95% confidence interval, 1.70 to 5.86]; P < 0.001) and lower urinary iodine excretion (hazard ratio per halving 1.89 [95% confidence interval, 1.32 to 2.63]; P < 0.001) were both associated with higher mortality in multivariable analyses. In male KTR, inadequate iodine intake and urinary iodine excretion were not associated with increased mortality (both P > 0.05).

conclusionsKTR have lower urinary iodine excretion compared with healthy controls and more frequently fell below the threshold for inadequate iodine intake, particularly among women. Inadequate iodine intake was independently associated with an increased mortality in female, but not in male KTR, underscoring a potential sex-specific vulnerability. These findings support further investigation into whether improving iodine status could reduce mortality, particularly among female KTR. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT02811835.

Indexed as

DietIodineKidney TransplantationAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedNutritional StatusRisk FactorsSex FactorsIodinekidney transplantationmortalitymortality risknutritionsurvivaltransplantationwomen's health

Identifiers

PMID41911029
PMCPMC13268380

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.