Evidence map›Paper›PMID 41911287›Full record

ArticleFEBS open bio2026

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.

Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang-An Yin, Ronald Melki, Edward A Fon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sandesh NeupaneInstitute for the Science of the Aging Brain, St. Gallen, Switzerland.
Lea NikolićLaboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.ORCID https://orcid.org/0000-0001-8792-7199
Lorenzo MaraioInstitute for the Science of the Aging Brain, St. Gallen, Switzerland.
Thomas GoiranNeurodegenerative Diseases Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Canada.
Nathan KarpilovskyNeurodegenerative Diseases Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Canada.
Stefano SellittoDepartment of Biology, University of Padova, Italy.ORCID https://orcid.org/0000-0003-2579-6271
Vangelis BourisInstitute for the Science of the Aging Brain, St. Gallen, Switzerland.
Jiang-An YinAging and Regeneration Center, School of Basic Medical Sciences, Tsinghua University, Beijing, P. R. China.
Ronald MelkiInstitut François Jacob (MIRCen) and CNRS, Fontenay-aux-Roses, France.ORCID https://orcid.org/0000-0003-0000-7096
Edward A FonNeurodegenerative Diseases Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Canada.
Adriano AguzziInstitute for the Science of the Aging Brain, St. Gallen, Switzerland.
Elena De CeccoInstitute for the Science of the Aging Brain, St. Gallen, Switzerland.ORCID https://orcid.org/0000-0002-0148-2596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Parkinson's disease and other synucleinopathies, αSynuclein (αSyn) misfolds and forms Ser

Indexed as

alpha-SynucleinMitochondrial ProteinsEndoplasmic ReticulumHEK293 CellsHumansMitochondriaParkinson DiseaseProtein AggregatesProtein Aggregation, Pathologicalalpha-SynucleinMitochondrial ProteinsProtein Aggregatesautophagy‐lysosomal pathwayCRISPR screeningmitochondrial dysfunctionneurodegenerationsynucleinopathiesαSynuclein aggregation

Identifiers

PMID41911287
PMCPMC13398675

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.