Incense Aerosol-Induced Neurotoxicity Disrupts α-Synuclein Homeostasis in a Cellular Parkinson's Disease Model, Distinct from Cigarette Aerosols.

Yi-En Tseng, Ming-Chu Teng, Yu-Siou Huang, Chia-Hsuan Pan, Yuan-Pin Chang, Chia C Wang, Hsiu-Fang Fan

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Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

7 authors.

Yi-En TsengInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Ming-Chu TengInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Yu-Siou HuangInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Chia-Hsuan PanDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Yuan-Pin ChangDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.ORCID 0000-0002-2205-6262

Chia C WangDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.ORCID 0000-0003-3214-9937

Hsiu-Fang FanInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.ORCID 0000-0002-4870-351X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incense burning is a widespread indoor combustion practice, yet its neurotoxic potential and impact on α-synuclein (α-Syn) proteostasis remain poorly defined. Using SH-SY5Y cells overexpressing α-Syn as a cellular Parkinson's disease model, we exposed cells to size-fractionated incense aerosol extracts (IAE) prepared as organic-phase (OP) or water-soluble phase (WP). α-Syn overexpression augmented vulnerability to IAE, producing greater losses in viability and pronounced increases in intracellular hydrogen peroxide (H

Indexed as

Aerosolsalpha-SynucleinParkinson DiseaseTobacco Smoke PollutionAir Pollution, IndoorCaspase 1Caspase 3Cell Line, TumorGene Expression RegulationHomeostasisHumansMembrane Potential, MitochondrialNervous SystemNeurotoxicity SyndromesTobacco ProductsAerosolsalpha-SynucleinCaspase 1Caspase 3Tobacco Smoke Pollution

Identifiers

PMID41911441

DOI10.1021/acs.chemrestox.6c00091

PMCPMC13100986

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.