Evidence map›Paper›PMID 41911448›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Fatty acid regulation of feeding in

Feimei Zhu, Jorge Iván Castillo-Quan, Takafumi Ogawa, Ziyun Wu, Lang Ding, Mansi Sura, Yoshiyuki Watanabe, Hannah Lentschat, L Paulette Fernández-Cárdenas, Ugur Dag and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Feimei ZhuResearch Division, Joslin Diabetes Center, Boston, MA 02215.
Jorge Iván Castillo-QuanResearch Division, Joslin Diabetes Center, Boston, MA 02215.ORCID 0000-0002-6324-2854
Takafumi OgawaResearch Division, Joslin Diabetes Center, Boston, MA 02215.
Ziyun WuResearch Division, Joslin Diabetes Center, Boston, MA 02215.ORCID 0000-0001-8239-1890
Lang DingHHMI, Janelia Research Campus, Ashburn, VA 19700.
Mansi SuraResearch Division, Joslin Diabetes Center, Boston, MA 02215.
Yoshiyuki WatanabeResearch Division, Joslin Diabetes Center, Boston, MA 02215.
Hannah LentschatInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04103, Germany.
L Paulette Fernández-CárdenasResearch Division, Joslin Diabetes Center, Boston, MA 02215.
Ugur DagPicower Institute for Learning and Memory and HHMI, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
Annette Beck-SickingerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-4560-8020
Meng C WangHHMI, Janelia Research Campus, Ashburn, VA 19700.
C Ronald KahnResearch Division, Joslin Diabetes Center, Boston, MA 02215.ORCID 0000-0002-7583-9228
T Keith BlackwellResearch Division, Joslin Diabetes Center, Boston, MA 02215.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Uncovering Conserved Lipid Homeostasis Mechanisms that Mediate Longevity after Germ Cell Loss in C. ElegansR01AG054215 · NIA · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 2017 to 2026
$3.9M
Joslin-BIDMC Postbac Program in Diabetes and MetabolismR25DK140752 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 2024 to 2026
$1.2M
Deutsche Forschungsgemeinschaft (DFG) SFB1423HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK031036/DK128429/DK121967/DK082659/R35GM122610HHS | NIH | National Institute of General Medical Sciences (NIGMS) 2R35GM122610MEXT | Japan Society for the Promotion of Science (JSPS) S2902NIA NIH HHS R01 AG054215NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R25 DK140752
6 · The paper itself

Abstract

Regulation of food intake in mammals is complex and controlled by an interplay between hedonic and homeostatic signals, including hormones like leptin, which senses fat storage and suppresses food intake.

Indexed as

Caenorhabditis elegansFatty AcidsFeeding BehaviorGlucagon-Like Peptide 1Signal TransductionAnimalsCaenorhabditis elegans ProteinsGlucagon-Like Peptide-1 ReceptorCaenorhabditis elegans ProteinsFatty AcidsGlucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptorappetite and feeding regulationER signalingfatty acid metabolismGLP-1 receptor agonistinsulin sensitivity

Identifiers

PMID41911448
PMCPMC13056082

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.