Evidence map›Paper›PMID 41912236›Full record

ArticleThe Journal of international medical research2026

Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey.

Junzhi Liu, Xiaoyi Li, Kun Xu, Xinfeng Chen, Jie Jiang, Zhenmin Liu, Jiangang Chen, Haixia Liu, Dehua Hu, Jianwei Liu and 2 more

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Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Junzhi LiuCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.ORCID 0009-0008-1787-6697
Xiaoyi LiCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Kun XuCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Xinfeng ChenCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Jie JiangCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Zhenmin LiuCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Jiangang ChenCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Haixia LiuCollege of Life Sciences, Central South University, China.
Dehua HuCollege of Life Sciences, Central South University, China.
Jianwei LiuCollege of Life Sciences, Central South University, China.
Bing ZhengCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.
Hua ZhuCurrent affiliation: Department of Urology Surgery, Nantong First People's Hospital; Nantong First People's Hospital, Southeast University; Affiliated Nantong Clinical College of Nantong University, Nantong First People's Hospital; Affiliated Hospital 2 of Nantong University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveKidney stones, affecting approximately 10% of adults worldwide, pose substantial clinical and economic burdens. Although insulin resistance is implicated in lithogenesis, the association between estimated glucose disposal rate, a surrogate marker of insulin sensitivity, and kidney stone risk, as well as the mediating role of lipid markers, remains unexplored.MethodsThis cross-sectional study analyzed data from 11,282 participants in the National Health and Nutrition Examination Survey (2007-2018). Estimated glucose disposal rate was calculated using waist circumference, hypertension status, and glycosylated hemoglobin. History of kidney stones was self-reported. Weighted logistic regression, restricted cubic spline models, and mediation analysis were used to assess associations, adjusting for sociodemographic, metabolic, and renal covariates.ResultsIn our study, the mean age of participants was 47.71 years, and the prevalence of kidney stones was 9.8%. In the fully adjusted multifactorial logistic regression model, participants in the highest quartile of estimated glucose disposal rate (Q4) were 44% less likely to develop stones than those in Q1 (odds ratio: 0.56, 95% confidence interval: 0.37-0.83; p

Indexed as

Blood GlucoseGlucoseKidney CalculiLipoproteins, HDLAdultCross-Sectional StudiesFemaleHumansInsulin ResistanceMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsBlood GlucoseGlucoseLipoproteins, HDLestimated glucose disposal ratehigh-density lipoproteinInsulin resistanceKidney stonesmediation analysis

Identifiers

PMID41912236
PMCPMC13047278

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.