Evidence map›Paper›PMID 41912450›Full record

ArticleRenal failure2026

ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway.

Honghong Wang, Jie Guo, Qingqing Wang, Fanghao Cai, Shan Jiang, Lingyan Fei, Gensheng Zhang, Guizhen Yu, Bingjue Li, Jingyi Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Honghong WangKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Jie GuoKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Qingqing WangScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Fanghao CaiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Shan JiangDepartment of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Lingyan FeiDepartment of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Gensheng ZhangDepartment of Urology, Pediatric Urolith Center, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Pediatric Nephrology & Urology Medical Research Center, Hangzhou, China.
Guizhen YuKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Bingjue LiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Jingyi ZhouKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Zheng LiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Fei HanKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
En Yin LaiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Suhan ZhouKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM). Accumulated reactive oxygen species (ROS) and oxidative stress-induced ferroptosis and mitochondrial dysfunction play a critical role in the development of DN. The aim of this research was to investigate the protective role and mechanism of ADAMTS13 in regulating oxidative stress-mediated cell death via nuclear factor erythroid 2-related factor 2 (Nrf2) in DN. In this study, DN patients with renal biopsy-confirmed and healthy controls were collected.

Indexed as

ADAMTS13 ProteinDiabetic NephropathiesNF-E2-Related Factor 2AnimalsDiabetes Mellitus, ExperimentalDisease Models, AnimalHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMiddle AgedNitric Oxide Synthase Type IIIOxidative StressReactive Oxygen SpeciesSignal TransductionADAMTS13 ProteinADAMTS13 protein, humanNFE2L2 protein, humanNF-E2-Related Factor 2Nitric Oxide Synthase Type IIINOS3 protein, humanReactive Oxygen SpeciesADAMTS13Diabetic nephropathyEndothelial dysfunctioneNOSNrf2

Identifiers

PMID41912450
PMCPMC13037144

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.