Evidence map›Paper›PMID 41912452›Full record

ArticleHippocampus2026

rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration.

Stephen Duncan, Sulaiman Rehman, Vladislava Segen, Irene Choi, Sami Lawrence, Om Kalani, Lisette Gold, Lillian Goldman, Sophia Ramlo, Kylene Stickel and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Stephen DuncanDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0009-0001-1506-0933
Sulaiman RehmanDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0009-0008-3797-1480
Vladislava SegenGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.ORCID 0000-0002-6677-723X
Irene ChoiDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Sami LawrenceDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Om KalaniDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Lisette GoldDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Lillian GoldmanDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0009-0006-7047-7965
Sophia RamloDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Kylene StickelDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Dylan LayfieldDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-0694-0998
Thomas WolbersGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.ORCID 0000-0003-2943-8949
Zoran TiganjDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0001-5581-9636
Ehren L NewmanDepartment of Psychology & Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0001-7006-4112

Funding

CRCNS: Scale-invariant navigation and its degradation in Alzheimer's diseaseR01AG076198 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI NEWMAN, EHREN L. · 2021 to 2023
$1.0M
Indiana University Office for Vice President for Research bridge fundingLilly Endowment, Inc., Indiana University Pervasive Technology InstituteNIA NIH HHS R01 AG076198NIH HHS R01 AG076198
6 · The paper itself

Abstract

Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). In humans, TCT has shown promise for the early diagnosis of Alzheimer's disease. In rodents, however, path integration is assessed using a wide variety of tasks, but none of which currently provide a homologue for the TCT. As rodents are routinely used as preclinical models, homologous path integration tasks that result in comparable performance metrics between species are important. In the present study, we developed and tested a novel rodent version of the triangle completion task to enhance cross-species comparability of path integration performance. Rats were able to comprehend and perform the task. A group of Alzheimer's disease model rats (TgF344-AD) exhibited similar path integration performance to their wild-type littermates. This work establishes a novel rodent homologue of the triangle completion task, facilitating enhanced reverse translational study of human path integration.

Indexed as

Alzheimer DiseaseSpace PerceptionSpatial NavigationAnimalsDisease Models, AnimalMaleMaze LearningRatsRats, Transgenic

Identifiers

PMID41912452
PMCPMC13035483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.