Evidence map›Paper›PMID 41912818›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2026

Pyrrolizidine Alkaloids and Toxic Microelements in Above-Ground Parts of Nonea rossica (Boraginaceae).

V V Velichko, D S Kruglov, D N Olennikov, K I Ershov, M E Kartashova

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

V V VelichkoNovosibirsk State Medical University, Novosibirsk, Russia. velichkvik@rambler.ru.
D S KruglovNovosibirsk State Medical University, Novosibirsk, Russia.
D N OlennikovInstitute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences, Ulan-Ude, Russia.
K I ErshovNovosibirsk State Medical University, Novosibirsk, Russia.
M E KartashovaNovosibirsk State Medical University, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonea rossica Steven is an herbaceous perennial of the family Boraginaceae and is of interest as a source of herbal medicine raw material in view of its indirect anticoagulant properties and antimicrobial and antifungal activities. At the same time, Boraginaceae species are known to contain pyrrolizidine alkaloids that have a hepatotoxic effect, which makes it problematic to use plant-derived preparations. Along with alkaloids, toxic trace elements contribute to toxicity of herbal preparations. The objective of this work was to study the toxic components in the N. rossica above-ground parts. The composition and content of alkaloids were determined by HPLC. Quantitative determination of trace elements was carried out using inductively coupled plasma mass spectrometry. The pyrrolizidine enantiomers intermedine and lycopsamine and their derivatives were detected; their total content in plant raw materials was less than 20 000 μg/kg. The content of toxic elements, such as As, Cd, Pb, Hg, Be, Sr, Sb, Tl, and U, did not exceed legally permissible concentrations.

Indexed as

BoraginaceaePyrrolizidine AlkaloidsTrace ElementsPyrrolizidine AlkaloidsTrace ElementsBoraginaceaeintermedinelycopsamineNonea rossicatrace elements

Identifiers

PMID41912818

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.