ArticleIn vitro cellular & developmental biology. Animal2026
Elevated intravesical pressure promotes circulating tumor cell release in an orthotopic mouse model of bladder cancer.
Article in In vitro cellular & developmental biology. Animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Elevated intravesical pressure during transurethral resection of bladder tumor (TURBT) is hypothesized to facilitate the release of circulating tumor cells (CTCs), potentially increasing the risk of hematogenous metastasis. However, the causal relationship between intravesical pressure and CTC dissemination remains unclear. This study aimed to investigate the effect of different intravesical pressure levels on the release of CTCs in an orthotopic mouse model of bladder cancer. An orthotopic bladder cancer model was established in female C57BL/6 mice by implanting MB49-luc cells. Tumor-bearing mice were randomly assigned to three groups (n = 6 per group) subjected to different intravesical pressures for 20 min: 0 cmH
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