Evidence map›Paper›PMID 41912985›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease.

Tianbai Li, Meichen Liu, Peng Zhang, Song Li, Tao Qiu, Xinhui Qiu, Bo Sun, Huaibin Cai, Cong Liu, Junliang Yuan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianbai LiKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Meichen LiuKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Peng ZhangDepartment of Urology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Song LiKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Tao QiuKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Xinhui QiuKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Bo SunDepartment of Radiology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Huaibin CaiTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Cong LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Junliang YuanDepartment of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.
Weidong LeKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Alzheimer's Disease Neuroimaging Initiative

Funding

Intramural Research Programs of the National Institute on Aging, NIH AG000928 to H.C.Intramural Research Programs of the National Institute on Aging, NIH ZIA AG000944 to H.C.National Key Science and Technology Project-Changping National Laboratory Research Project 2025B-07-10National Natural Science Foundation of China (NSFC) 22376006National Natural Science Foundation of China (NSFC) 32220103006National Natural Science Foundation of China (NSFC) 82271524National Science & Technology Major Program on "Brain Science and Brain-Inspired Research" 2022ZD0211604National Science & Technology Major Program on "Brain Science and Brain-Inspired Research" 2022ZD0211607Natural Science Foundation of Liaoning Province 2023-MSLH-029
6 · The paper itself

Abstract

introductionSleep disturbance is increasingly recognized as a risk factor for Alzheimer's disease (AD), but longitudinal clinical evidence linking sleep behaviors to cerebrospinal fluid (CSF) amyloid beta (Aβ) dynamics and related proteomic signatures remains limited.

methodsWe analyzed 1205 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to examine associations between sleep disturbance, CSF Aβ42 level, and cognition. To prioritize molecular candidates associated with these phenotypes, we integrated CSF proteomics with weighted gene co-expression network analysis (WGCNA) and two-sample Mendelian randomization (MR).

resultsBaseline sleep disturbance was associated with a faster rate of longitudinal CSF Aβ42 decline. WGCNA identified a protein module associated with sleep disturbance and Aβ42, within which MR supported effects of sleep disturbance on multiple proteins. Among these, interferon γ-inducible protein 16 is a candidate link between sleep disturbance and Aβ pathology. DISCUSSION: Our findings suggest that sleep disturbance accelerates Aβ pathology, and implicate IFI16-related pathway as a link between disrupted sleep and AD progression.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPeptide FragmentsSleep Wake DisordersAgedAged, 80 and overBiomarkersDisease ProgressionFemaleHumansMaleMendelian Randomization AnalysisProteomicsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide FragmentsAlzheimer's diseaseamyloid betacerebrospinal fluidproteomicssleep disturbance

Identifiers

PMID41912985
PMCPMC13140711

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.