ReviewCell communication and signaling : CCS2026
Mitochondria and the epigenome: maternal co-inheritance and crosstalk from oocyte to embryo.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mitochondria, as central hubs of metabolism and bioenergetics, are essential for oocyte maturation and early embryonic development. Their functions are intricately linked to epigenetic mechanisms, forming interconnected networks that govern gene expression across both nuclear and mitochondrial genomes. Mitochondrial epigenetic programming established during oogenesis is transmitted maternally through cytoplasmic inheritance, underscoring mitochondrial quality as a heritable determinant of developmental competence. Expanding research has broadened epigenetic regulation beyond the nucleus, showing that mitochondrial DNA (mtDNA) also undergoes dynamic modifications, including methylation, which offer fresh insights into bidirectional mitochondrial-nuclear communication. This review highlights how nuclear and mitochondrial genomes mutually influence one another in terms of mitochondrial function and epigenetic landscape. We particularly discuss advance in mtDNA methylation, its inheritance during oogenesis, and the contribution of accumulating mitochondrial mutations. Finally, we outline how diverse epigenetic regulators shape mitochondrial physiology and how mitochondrial metabolism and composition, in turn, feedback on the epigenome during development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.