ArticleLaboratory animals2026
Isolated perfusion of pig kidney segments to study renal function: a translational model for human kidneys.
Article in Laboratory animals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolated kidney perfusion forms the bridge between in vitro and in vivo experiments and is mainly performed with rodent kidneys. It enables the controlled investigation of kidney function without systemic influences and is therefore currently, for instance, considered the gold standard for investigating the regulation of renin release, a central regulator of blood pressure. Renin secretion is controlled by several intrarenal signalling cascades and thus cannot be fully modelled in cell cultures. On the other hand, the in vivo investigation of renin release is confounded by systemic counter-regulatory systemic mechanisms. For ethical and logistical reasons, human kidney tissue has not been used for isolated organ perfusion yet. To reduce the use of rodents and to achieve the translation to larger species, including humans, we developed a method for isolated perfusion of slaughterhouse pig kidney segments. This method allows for future use with human kidney segments obtained from nephrectomies. Pig kidney segments were perfused at constant pressure and renin secretion was determined. The sympathomimetic agent isoproterenol, the Ca
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.