Evidence map›Paper›PMID 41914674›Full record

ArticleACS infectious diseases2026

Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of

Daniel Opperman, Tayla Rabie, Marché Maré, Mariska Naude, Mariette van der Watt, Jessica L Thibaud, Megan Shannon, Nicole Sanders, Judith M Bolscher, Rianne van der Laak and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Daniel OppermanDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.
Tayla RabieDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.
Marché MaréDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.
Mariska NaudeDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.
Mariette van der WattInstitute for Sustainable Malaria Control, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.
Jessica L ThibaudDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Megan ShannonDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Nicole SandersDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Judith M BolscherTropIQ Health Sciences, Transistorweg 5, 6534AT Nijmegen, The Netherlands.
Rianne van der LaakTropIQ Health Sciences, Transistorweg 5, 6534AT Nijmegen, The Netherlands.
Rowy WillemsenTropIQ Health Sciences, Transistorweg 5, 6534AT Nijmegen, The Netherlands.
Alfred BronkhorstTropIQ Health Sciences, Transistorweg 5, 6534AT Nijmegen, The Netherlands.
Nonlawat BoonyalaiDivision of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K.
Marcus C S LeeDivision of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K.
Lyn-Marié BirkholtzDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Private bag X20, Hatfield, Pretoria 0002, South Africa.ORCID 0000-0001-5888-2905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing rise in antimalarial drug resistance underscores the urgent need for new drug candidates that specifically target novel mechanisms. Malaria parasites employ various epigenetic strategies to regulate gene expression throughout their complex life cycle, with histone lysine acetylation and methylation being well-studied and targeted by new antiplasmodials. By contrast, arginine methylation remains poorly explored.

Indexed as

AntimalarialsEnzyme InhibitorsPlasmodium falciparumProtein-Arginine N-MethyltransferasesProtozoan ProteinsHumansStructure-Activity RelationshipAntimalarialsEnzyme InhibitorsProtein-Arginine N-MethyltransferasesProtozoan Proteinsarginine methylationPlasmodium falciparumPRMTPRMT inhibitors

Identifiers

PMID41914674
PMCPMC13077687

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.