ArticleExperimental physiology2026
Pressure-dependent coupling between arterial pressure and intercostal muscle blood-flow index during acute hypotension in humans.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Pressure-dependent coupling between arterial pressure and intercostal muscle blood-flow index during acute hypotension in humans.Experimental physiology · 2026Article
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Abstract
Regulation of respiratory muscle blood flow during acute systemic hypotension remains poorly understood in humans because continuous assessment of microvascular perfusion during rapid haemodynamic transients has been technically challenging. Using diffuse correlation spectroscopy, we investigated second-by-second coupling between mean arterial pressure (MAP) and intercostal muscle blood-flow index (BFI) during an abrupt hypotensive stimulus in healthy humans. Fifteen young men underwent 5 min of suprasystolic bilateral thigh occlusion followed by rapid cuff release. The MAP and intercostal BFI were analysed at 1 Hz over drop (0-10 s) and recovery (10-20 s) phases. Phase-specific MAP-BFI gain (%BFI per 1% change in MAP) was estimated using linear mixed-effects models, with within-participant centring. Immediately after cuff release, MAP and BFI decreased almost concomitantly, reached nadirs at ∼10 s and recovered towards baseline within the next ∼10 s. Phase-averaged reductions in BFI were associated with reductions in MAP during the drop phase (Pearson's r = 0.66, P = 0.00701). Mixed-effects modelling revealed near-unity MAP-BFI gain in both phases (drop, 0.89 [95% confidence interval 0.63-1.15], P < 0.001 vs. 0, P = 0.417 vs. 1; recovery, 0.95 [0.50-1.40], P < 0.001 vs. 0, P = 0.830 vs. 1), with no phase difference (recovery-drop = 0.06 [-0.46 to 0.58], P = 0.824). Individual-level gains showed greater variability, particularly during recovery. These findings demonstrate tight pressure-BFI coupling over seconds-long time scales, indicating that perfusion pressure is a key determinant of intercostal microvascular blood-flow dynamics during acute hypotensive stress.
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