ArticleJournal of pregnancy2026
The Protective Effect of Vitamin D Against Necroptosis in Preeclampsia.
Article in Journal of pregnancy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Regulated Cell Death at the Maternal-Fetal Interface in Preeclampsia: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, Autophagic Cell Death, and Cuproptosis - A Narrative Review.International journal of general medicine · 2026Review
- The Protective Effect of Vitamin D Against Necroptosis in Preeclampsia.Journal of pregnancy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePreeclampsia is correlated with an inflammatory condition. Necroptosis is a programmed cell death with an inflammatory state. Vitamin D has anti-inflammatory properties; however, there has been no study linking vitamin D and necroptosis in preeclampsia. This study is aimed at evaluating vitamin D status and necroptosis activity in preeclampsia.
methodsA cross-sectional study was conducted in Jakarta during 2021-2023. Subjects were grouped into normal and preeclampsia. Following delivery, venous blood and placental samples were taken. Serum and placental 25(OH)D assays were performed by LC-MS/MS. Immunohistochemistry was performed to measure necrosomes RIPK1, RIPK3, and MLKL in trophoblast and endothelial.
resultsA total of 60 subjects participated (31 normal and 29 preeclampsia). The preeclampsia group had lower gestational age (35 vs. 38 weeks), lower birth weight (3080.33 ± 454.62 g vs. 2283.27 ± 833.63 g), lower placental weight (580.40 ± 129.36 g vs. 453.06 ± 173.65 g), lower placental 25(OH)D (15.00 [3.50-58.00] vs. 26.50 [5.00-153.00] ng/mL, p = 0.014), and higher trophoblast RIPK3 (93.88 [23.94] vs. 76.20 [20.59], p = 0.003). A mild to moderate negative correlation between placental 25(OH)D and trophoblast RIPK3 (-0.352, p = 0.003), endothelial RIPK3 (r = -0.244, p = 0.03), and trophoblast MLKL (r = -0.296, r - 0.011) were observed.
conclusionLower placental 25(OH)D concentration is associated with an increased placental necroptosis activity in preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.