ArticleBiomaterials science2026
Exosome-niosome hybrid oxygen carrier for protection against acetaminophen-induced acute liver injury.
Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Acetaminophen (APAP) overdose is one of the contributing factors for acute liver injury (ALI), caused by a hypoxic microenvironment, elevated oxidative stress, and pro-inflammatory signaling. In this work, we present an exosome-niosome hybrid oxygen carrier (ENh-OC) composed of polysorbate 80, Pluronic® F-127, medium chain triglyceride oil, and blueberry-derived exosomes. We propose that our delivery system shields the liver tissue from localized hypoxia by maintaining sustained oxygen delivery, and the antioxidant and anti-inflammatory components present in the exosomes enhance the hepatoprotective effect. The hydrodynamic diameter of ENh-OCs is 74.0 ± 30.8 nm with a zeta potential of -13.2 ± 0.5 mV, and oxygen holding capacity of 54.3 ± 1.5 mg L
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