ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2026
Clinical predictors of resilience following total knee arthroplasty: the PRIME-KNEE study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- An Exploratory Stability Selection (ESS) framework for robust predictor discovery: An application to physical resilience in aging populations.Experimental gerontology · 2026Article
- Immune Biomarker Signatures as Predictors of Functional and Pain Recovery After Total Knee Arthroplasty in Older Adults.medRxiv : the preprint server for health sciences · 2026Article
- A Reproducible Pipeline for Processing Commercial Wearable Step-Count Data in Aging Cohorts: Application and Evaluation in the STRRIDE-PD Reunion Study.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundWe aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasible measures predicting recovery.
methodsProspective cohort study in a single academic medical center. Adults ≥60 years (n = 203) scheduled for elective TKA had preoperative assessments of physical reserve (3-min walk test, grip strength), psychological reserve (PHQ-9, Resilience Scale), social support (emotional support scale, financial resource sufficiency, education level), and cognitive reserve (3MS, Trail Making Test Part B, Digit Symbol Substitution Test, 15-item recall). Provocative tests with experimental stressors included dual-task gait speed, and functional near infrared spectroscopy (fNIRS). Outcomes were the PROMIS pain scales, the lower extremity gain scale, and average daily step counts measured at postoperative day 1-7 and months 1, 2, 4, and 6. Latent class trajectory analysis defined common recovery patterns for each outcome.
resultsFor each outcome, 3-4 recovery trajectory groups were defined. Overall, 7% of participants were in the highest recovery group in all 4 outcomes and 20% in the lowest for all outcomes. Preoperative depression score, cognitive tests, emotional support scale, 3-min walk distance, and grip strength were significantly different across resilience groups in multiple outcomes. Provocative tests were not predictive of recovery.
conclusionsRecovery trajectories after TKA are predicted by physical, cognitive, and psychological reserve measures. Results inform future resilience research and may allow for shared decision-making and targeted preoperative optimization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.