Evidence map›Paper›PMID 41915123›Full record

ArticleAnnals of biomedical engineering2026

Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development.

Michael S DiStefano, Rebecca L Betts, Courtney A Nuss, Srish S Chenna, Louis J Soslowsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael S DiStefanoMcKay Orthopaedic Laboratory, University of Pennsylvania, 307A Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA.
Rebecca L BettsMcKay Orthopaedic Laboratory, University of Pennsylvania, 307A Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA.
Courtney A NussMcKay Orthopaedic Laboratory, University of Pennsylvania, 307A Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA.
Srish S ChennaMcKay Orthopaedic Laboratory, University of Pennsylvania, 307A Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA.
Louis J SoslowskyMcKay Orthopaedic Laboratory, University of Pennsylvania, 307A Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA. soslowsk@upenn.edu.ORCID http://orcid.org/0000-0001-5498-7785

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Critical role of collagen XII in cell- and matrix-mediated mechanisms regulating acquisition of tendon structure and function in development and the injury responseR01AR078790 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DYMENT, NATHANIEL A., SOSLOWSKY, LOUIS J · 2021 to 2025
$1.7M
Regulatory Mechanisms of Collagen XII in Establishing Achilles Tendon Hierarchical Structure and Function in Postnatal Development and HealingF31AR083255 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DISTEFANO, MICHAEL STEVEN · 2023 to 2025
$146k
NIAMS NIH HHS F31 AR083255NIAMS NIH HHS F31AR083255NIAMS NIH HHS P30 AR069619NIAMS NIH HHS P30AR069619NIAMS NIH HHS R01 AR078790NIAMS NIH HHS R01AR078790
6 · The paper itself

Abstract

Tendons rely on hierarchical extracellular matrix organization for proper growth and mechanical function, but the tendon-specific role of collagen XII in this process remains poorly defined. The purpose of this study was to determine how tendon-targeted loss of collagen XII influences Achilles tendon structure, mechanics, and gene expression across key stages of postnatal development. Using tendon-targeted Scx-Cre;Col12a1

Indexed as

Achilles tendonCollagen XIIGene expressionStructure functionTendon development

Identifiers

PMID41915123
PMCPMC13452076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.