ArticlePediatric nephrology (Berlin, Germany)2026
Estimating the association of hypertensive disorders of pregnancy with offspring kidney function from adolescence into young adulthood.
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Hypertensive disorders of pregnancy and offspring's kidney health.Pediatric nephrology (Berlin, Germany) · 2026Article
- Revisiting the null association between hypertensive disorders of pregnancy and offspring kidney function: methodological considerations.Pediatric nephrology (Berlin, Germany) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTo estimate the association of hypertensive disorders of pregnancy (HDP) with offspring kidney function in adolescence and young adulthood in individuals born preterm with very low birth weight.
methodsSecondary analysis of data from a prospective cohort study of individuals born preterm with very low or extremely low birth weight (< 1500 g). The 213 participants were assessed at 14-15 and 19-23 years of age. Outcomes were estimated glomerular filtration rate (eGFR) and first-morning urine albumin-to-creatinine ratio (ACR). We estimated the relationships with multivariable generalized linear models informed by directed acyclic graphs. Causal mediation analysis was also performed to evaluate if adolescent kidney function indirectly mediated the effect of HDP on young adulthood kidney function.
resultsThirty-seven percent (n = 79) were exposed to HDP. Kidney function in adolescence was associated with kidney function in young adulthood (eGFR adjusted β 0.48 mL/min/1.73 m
conclusionsWe found no significant association between HDP and offspring kidney function in adolescence and young adulthood and no evidence of mediation through adolescent kidney function. Next steps in this research may look to investigate the relationship of severity of prematurity on offspring kidney function, as HDPs are a factor in premature births and the degree of prematurity.
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Registered trials
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