Evidence mapPaperPMID 41915433Full record

ReviewPhysiology (Bethesda, Md.)2026

Ana D Alcocer, Elizabeth H Rush, Timothy J Mead

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ana D AlcocerDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Elizabeth H RushDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Timothy J MeadDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0003-1891-3652

Funding

Impact of microfibril turnover on vascular development and diseaseR01HL156987 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · 2024 to 2025
$797k
HHS | National Institutes of Health (NIH) HL156987NHLBI NIH HHS R01 HL156987
6 · The paper itself

Abstract

The ADAMTS family are extracellular matrix (ECM) proteins and enzymes involved in regulating tissue structure and function. The ECM is a network of proteins and polysaccharides surrounding the cells that provide support and maintain cellular function. Mutations to proteins in the ECM lead to systemic connective tissue disorders by disrupting the structural integrity and maintenance of the ECM, resulting in ocular, musculoskeletal, skin, and cardiovascular abnormalities. Mutations that arise from the ADAMTS family lead to specific connective tissue disorders with distinct clinical characteristics. Here, we detail these distinct clinical features of major connective tissue disorders that arise from mutations in the ADAMTS family proteins. These include Ehlers Danlos syndrome arising from mutation in

Indexed as

ADAMTSADAMTSLclinical characteristicsconnective tissue disordersextracellular matrix

Identifiers

PMID41915433
PMCPMC13157330

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.