Evidence map›Paper›PMID 41915614›Full record

ArticleACS infectious diseases2026

In Vivo Trypanocidal Activity of the Drug Disulfiram Combined with Benznidazole.

Viviane Flores Xavier, Kátia da Silva Fonseca, Thays Helena Chaves Duarte, Flávia de Souza Marques, Lucas Resende Dutra Sousa, Aline Tonhela Ferraz, Fernanda Caetano Camini, Daniela Caldeira Costa Calsavara, Cláudia Martins Carneiro, Brian Alejandro Suárez Mantilla and 2 more

Abstract read
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In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Viviane Flores XavierLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Kátia da Silva FonsecaLaboratory of Immunopathology, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Thays Helena Chaves DuarteLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Flávia de Souza MarquesLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Lucas Resende Dutra SousaLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Aline Tonhela FerrazLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Fernanda Caetano CaminiLaboratory of Biochemistry Metabolic, Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Daniela Caldeira Costa CalsavaraLaboratory of Biochemistry Metabolic, Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Cláudia Martins CarneiroLaboratory of Immunopathology, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.
Brian Alejandro Suárez MantillaLaboratory Biochemistry of Tryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-220, Brazil.
Ariel Mariano SilberLaboratory Biochemistry of Tryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0003-4528-4732
Paula Melo de Abreu VieiraLaboratory of Morphopathology, Department of Biological Sciences, Nucleus of Biological Sciences Research, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-133, Brazil.ORCID 0000-0001-7033-7686

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is a significant public health problem with benznidazole (BZ) and nifurtimox being the only available treatments. This study evaluated the trypanocidal activity of disulfiram (DS) in Swiss mice infected with the Y and VL-10

Indexed as

Chagas DiseaseDisulfiramNitroimidazolesTrypanocidal AgentsTrypanosoma cruziAnimalsDrug Therapy, CombinationFemaleHeartMaleMiceParasitemiabenzonidazoleDisulfiramNitroimidazolesTrypanocidal Agentsdisulfirameffectivenessin vivotrypanocidal activityTrypanosoma cruzi

Identifiers

PMID41915614
PMCPMC13077684

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.