Evidence map›Paper›PMID 41915846›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Tailored Porous Bimetallic Nanozyme Platform for Full-Cycle Therapeutics of Intestinal Ischemia/Reperfusion.

Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chenghao QiuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Wenjing XianDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Mengxue WangDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Guozhi ZhaoDepartment of Urology Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Yanhuo ZhangDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Zhiyu ZhouDepartment of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Bo ShengDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Zhuo ZhenDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Xie LiuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Shouwen DiaoDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Mengwei TuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Chen QiuDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Huixian WangDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Jianbo ZhangDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Peng ZhuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Tong LiDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.ORCID https://orcid.org/0000-0002-4283-0091

Funding

KuanRen Excellent Doctor Project kryc-yq-2220National Natural Science Foundation of China 82000596 82002024Natural Science Foundation of Chongqing, China CSTB2024NSCQ-KJFZMSX0101Natural Science Foundation of Chongqing, China cstc2021jcyj-msxmX0266Peak Discipline Clusters Program of the Second Affiliated Hospital, Chongqing Medical University 2024311Senior Medical Talents Program of Chongqing for Young and Middle-aged YuWeiRenNO.2023/10Wellcome Trust 202478
6 · The paper itself

Abstract

Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative-inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA-Cu-Ma nanocomposite functions as a dual-phase therapeutic platform with significant efficacy. It rapidly scavenges reactive oxygen species (ROS) (exhibiting a 50.15% higher clearance in vitro) and suppresses macrophage pyroptosis within 6 h post-I/R. Furthermore, it enhances mucosal integrity (1.98-fold Occludin upregulation) and angiogenesis (3.6-fold increase in CD31

Indexed as

IntestinesNanocompositesReperfusion InjuryAnimalsDisease Models, AnimalHumansReactive Oxygen SpeciesReactive Oxygen Speciesantioxidantdual‐phase therapyintestinal ischemia/reperfusion injuryPrussian blue nanozymetissue repair

Identifiers

PMID41915846
PMCPMC13285119

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.