Evidence mapPaperPMID 41915873Full record

ArticleJCO global oncology2026

Lower Allele Frequency of

Perapa Chotiprasidhi, Viviana P Gonzalez Umpierre, Yvonne Ayerki Nartey, Hunter B Miller, Adrienne F Gefre, Karina Sato-Espinoza, Daniel O'Brien, Jun Ma, Yaw Awuku, Adwoa Agyei-Nkansah and 24 more

Abstract read
In one paragraph

Article in JCO global oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Perapa ChotiprasidhiDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0009-0005-2023-4861
Viviana P Gonzalez UmpierreDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Yvonne Ayerki NarteyDepartment of Internal Medicine, Cape Coast Teaching Hospital, Cape Coast, Ghana.ORCID 0000-0003-2891-3082
Hunter B MillerDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0009-0008-7338-9586
Adrienne F GefreDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0009-0007-1798-2935
Karina Sato-EspinozaDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Daniel O'BrienDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN.
Jun MaDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN.ORCID 0000-0003-4354-2523
Yaw AwukuDepartment of Medicine and Therapeutics, School of Medicine, University of Health and Allied Sciences, Ho, Ghana.
Adwoa Agyei-NkansahDepartment of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana.ORCID 0000-0003-4662-4591
Mary AfiheneDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID 0000-0003-2318-4976
Amoako DuahDepartment of Medicine, University of Ghana Medical Centre, Legon, Ghana.ORCID 0000-0001-8104-7393
Sally BampohDepartment of Internal Medicine, Greater Accra Regional Hospital, Accra, Ghana.
Shadrack AsibeyDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.ORCID 0000-0002-4258-6885
Joshua AyawinDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.ORCID 0000-0002-1831-3182
Jun WangDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-2678-2456
Yinan ZhengDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-2006-7320
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Claudia HawkinsInstitute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0001-7228-6317
Robert MurphyCenter for Global Health, Department of Infectious Diseases, Chicago, IL.ORCID 0000-0003-3936-2052
Godwin ImadeCollege of Health Sciences, University of Jos, Jos, Nigeria.ORCID 0000-0001-5221-7699
Edith OkekeCollege of Health Sciences, University of Jos, Jos, Nigeria.ORCID 0000-0002-9278-1646
Alani AkanmuLagos University Teaching Hospital and College of Medicine, University of Lagos, Lagos, Nigeria.ORCID 0000-0001-7424-6060
Olufunmilayo LesiLagos University Teaching Hospital and College of Medicine, University of Lagos, Lagos, Nigeria.
Amelie PlymothDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Albert NyangaDepartment of Internal Medicine, Mbingo Baptist Hospital, Bamenda, Cameroon.ORCID 0000-0002-4884-7513
Norah NyahDepartment of Internal Medicine, Mbingo Baptist Hospital, Bamenda, Cameroon.
Mark TopazianDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0000-0003-1090-2844
Kimberlee KossickDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-8120-7617
Lisa A BoardmanDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Jose D DebesDepartment of Medicine and Division of Epidemiology and Community Health, School of Medicine, School of Public Health, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-1512-2604
Lewis R RobertsDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-7885-8574
Samuel O AntwiDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Jacksonville, FL.
Kirk J WangensteenDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-6042-6490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The higher incidence and earlier onset of HCC in sub-Saharan Africa suggest a potential role for a genetic predisposition. This study evaluated the association of

methodsThe study included 537 patients with HCC: United States (n = 348), Ghana (n = 79), Nigeria (n = 43), and Cameroon (n = 67). The control group had 2,872 cancer-free individuals: United States (n = 2,399), Ghana (n = 323), Nigeria (n = 85), and Cameroon (n = 65). Whole-exome sequencing was conducted using germline DNA, and data for

resultsIn the US cohort,

conclusionIn sub-Saharan African populations, there was a lower frequency of the HCC protective allele

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsTelomeraseAdultAgedFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsSub-Saharan African PeopleUnited StatesTelomeraseTERT protein, human

Identifiers

PMID41915873
PMCPMC13268121

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.