Evidence map›Paper›PMID 41916306›Full record

ArticleCell reports methods2026

Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer's disease.

Matthias Hebisch, Viola Kamin, Giovanna Cenini, Antonia Piazzesi, Fabio Bertan, Beatrice Weykopf, Julia Schlee, Senthilvelrajan Kaniyappan, Kevin J Washicosky, Doo Yeon Kim and 3 more

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In one paragraph

Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matthias HebischInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Viola KaminInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany.
Giovanna CeniniInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany.
Antonia PiazzesiGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Fabio BertanGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Beatrice WeykopfInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany; Cellomics Department, LIFE & BRAIN GmbH, 53127 Bonn, Germany.
Julia SchleeInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany.
Senthilvelrajan KaniyappanPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
Kevin J WashicoskyGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Doo Yeon KimGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Daniele BanoGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Michael PeitzInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany; Cell Programming Core Facility, University of Bonn, 53127 Bonn, Germany.
Oliver BrüstleInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, 53127 Bonn, Germany. Electronic address: brustle@uni-bonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims at implementing a 3D cell culture model of Alzheimer's disease (AD). To that end we engineered human induced pluripotent stem cell (iPSC)-derived neural stem cells to conditionally overexpress FAD mutant APP and PSEN1 variants. After differentiation in 3D basement membrane matrices, cultures exhibited increased Aβ

Indexed as

Alzheimer DiseaseModels, BiologicalPlaque, Amyloidtau ProteinsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCell DifferentiationHumansInduced Pluripotent Stem CellsMicrogliaMitochondriaNeural Stem CellsPresenilin-1Amyloid beta-PeptidesAmyloid beta-Protein PrecursorPresenilin-1tau Proteins3D cell cultureAlzheimerCP: neurosciencedisease modelinghuman stem cellsplaquetangle

Identifiers

PMID41916306
PMCPMC13106978

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.