Evidence map›Paper›PMID 41916669›Full record

Observational studyOpen heart2026

Genotype-phenotype correlations in patients with pathogenic/likely pathogenic titin variants from the Swiss Arrhythmogenic Cardiomyopathy Registry.

Nina Alissa Schätti, Siv Fokstuen, Argelia Medeiros-Domingo, Umberto Maccio, Matthias P Nägele, Fran Mikulicic, Andreas J Flammer, Lorraine Sazgary, Robert Manka, Verena Charlotte Wilzeck and 10 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nina Alissa SchättiDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0009-0009-3756-7004
Siv FokstuenDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Argelia Medeiros-DomingoSwiss Dnalysis Dübendorf, Zurich, Switzerland.
Umberto MaccioDepartment of Pathology, University Hospital Zurich, Zurich, Switzerland.
Matthias P NägeleDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-4065-6747
Fran MikulicicDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Andreas J FlammerDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Lorraine SazgaryDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Robert MankaDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Verena Charlotte WilzeckDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Felix TannerDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Christian GrebmerCardiology, Luzerner Kantonsspital, Lucerne, Switzerland.
Annina Salome VischerMedical Outpatient Department, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-5188-1723
Katja E OdeningDepartment of Cardiology, Inselspital University Hospital Bern, Bern, Switzerland.
Marina RiederDepartment of Cardiology, Inselspital University Hospital Bern, Bern, Switzerland.
Frank RuschitzkaDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Corinna BrunckhorstDepartment of Cardiology, University Hospital Zurich, Zürich, Switzerland.
Firat DuruDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Ardan M SagunerDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland ardansaguner@gmail.com.ORCID 0000-0003-1896-0803
Nicole R BonettiDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTruncating variants in the titin gene ( METHODS AND

resultsThis was a retrospective Swiss national study including 46 cardiomyopathy patients with pathogenic/likely pathogenic (P/LP)

conclusionsPatients with P/LP

Indexed as

Arrhythmogenic Right Ventricular DysplasiaConnectinMutationRegistriesAdultFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedPhenotypeRetrospective StudiesStroke VolumeSwitzerlandVentricular Function, LeftConnectinTTN protein, humanArrhythmias, CardiacCardiomyopathiesGENETICSMagnetic Resonance ImagingTachycardia, Ventricular

Identifiers

PMID41916669
PMCPMC13052549

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.