ArticleTranslational psychiatry2026
ADHD polygenic risk predicts neural signatures of cognitive control: Evidence from midfrontal theta dynamics.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive control mechanisms ensure goal-directedness in behaviour. Difficulties in cognitive control are well-established in conditions such as attention-deficit/hyperactivity disorder (ADHD) and autism. On the neural level, midfrontal theta (4-8 Hz) activity has emerged as a reliable correlate of cognitive control processes. Previous findings showed alterations in theta-based signals in both ADHD and autism, most notably an increase in the variability of theta phases across trials in cognitive control tasks, which was predictive of increased response time variability (RTV) as well. Crucially, recent work on twin studies has provided strong evidence for the genetic underpinning of these associations. Here, for the first time, we investigated whether polygenic scores (PGS) for ADHD and autism can predict RTV and EEG-derived theta-based measures of cognitive control in 454 participants. We found that PGS for ADHD, but not autism, accounted for a significant proportion of the variance in theta phase variability, captured via inter-trial coherence (ITC), in the well-standardised arrow-flanker task (2.5% of total variance, corresponding to 3.3% of the reliable variance). Furthermore, theta-ITC showed excellent test-retest reliability in our sample, indicating psychometric robustness, which in turn, further strengthens our findings. These results provide robust evidence linking genetic risk to neural measures and suggest that core dysregulation of the temporal coordination of control processes in ADHD is under genetic influence.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.