SynthesisScientific reports2026
Serum lipid alterations in oral squamous cell carcinoma and oral potentially malignant disorders: A systematic review and meta-analysis.
Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in serum lipids have been linked to systemic and neoplastic diseases, including oral malignancies. Lipid disturbances are reported inconsistently in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). This systematic review and meta-analysis clarifies lipid profile patterns across OPMD, OSCC, and healthy controls. Following PRISMA 2020 guidelines and PROSPERO registration, a comprehensive database search through November 2025 identified fifty-two eligible case-control studies comparing total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TGs) between OPMD, OSCC, and healthy individuals. Data were synthesized using a random-effects model, Cochran’s Q and I² statistics for heterogeneity and Risk of Bias. This meta-analysis showed significantly reduced TC, HDL, LDL, VLDL, and TGs in both OSCC and OPMD compared with healthy controls (p < 0.001), with greater reductions in OSCC. Direct comparisons between OSCC and OPMD revealed significant differences in TC (p = 0.025) and LDL (p = 0.04), while HDL and VLDL differences were not significant. High heterogeneity and mild publication bias for TC and TGs were observed. Results indicate an association between lipid profiles and disease stage, but prospective studies are needed to determine causality and diagnostic utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.