SynthesisOral radiology2026
Radiographic choice for skeletal maturation assessment: a systematic review of Cervical Vertebrae Method and Middle Phalanx Method.
Synthesis in Oral radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.International journal of molecular sciences · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to conduct a systematic review of the literature to provide an updated guide for clinicians in choosing the most appropriate radiographic method for skeletal age assessment and timing the pubertal growth spurt (PGS).
methodsThe review followed the PRISMA guidelines and used the PICOS strategy. Eligibility criteria focused on studies published in the last decade, directly comparing the Cervical Vertebrae Method (CVM) and the Middle Phalanx Method (MPM). Two reviewers performed the selection and a third reviewer intervened in cases of disagreement.
resultsAfter screening, thirteen studies were included. The analysis revealed that CVM and MPM are highly correlated and equivalent biological indicators. From the perspective of precision and reliability, the MPM method demonstrated excellent intra-observer reliability and clearly revealed the PGS. Conversely, CVM method showed reproducibility that is not improved by increasing clinical experience, but it achieved excellent accuracy when supported by Deep Learning (DL) and Artificial Intelligence (AI) systems.
conclusionThis review revealed that although MPM remains an excellent biological indicator, the equivalence of results, combined with the routine adoption of cephalometric radiography and the increasing implementation of AI, solidifies CVM as the preferred radiographic method. Consequently, subjecting the patient to an additional hand-wrist radiograph is unwarranted, relegating MPM to the role of a reserve indicator. CLINICAL RELEVANCE: AI and DL technologies are expected to standardize and drastically improve the objectivity and accuracy of CVM assessments, representing a crucial shift toward objective clinical diagnostics to eliminate the acknowledged inter- and intra-observer variability and optimize radiation dose management. The protocol was registered with the Prospective International Register of Systematic Reviews under number ID 1,110,124.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.