ArticleBiomedical engineering online2026
Assessing hemodynamic changes in diabetic patients with and without peripheral arterial disease using dynamic vascular optical spectroscopy.
Article in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPeripheral Arterial Disease (PAD) affects approximately 230 million people globally and is prevalent in 20%-50% of individuals with diabetes. Current diagnostic tools, such as the ankle-brachial index, have limited sensitivity in diabetic populations. This study utilizes dynamic vascular optical spectroscopy (DVOS) at thigh occlusion pressures of 60 and 100 mmHg to examine hemodynamic responses in the feet of diabetic patients, primarily aiming to enhance the detection of PAD in this group. We conducted a prospective cohort study involving 118 diabetic patients with PAD (50 males; age: 59.1 ± 7.9 years) and 118 diabetic subjects without PAD (52 males; age: 54.8 ± 13.7 years). DVOS was used to measure changes in oxyhemoglobin (ΔHbO), hemoglobin flow (HF), and tissue oxygen consumption (VO
resultsThe 60-mmHg occlusion revealed clearer hemodynamic differences than the 100-mmHg. During 60-mmHg occlusion, mean values for ΔHbO (2.0 ± 1.74 μmol), HF (0.86 ± 0.49 μmol/s), and VO
conclusionsHemodynamic parameters measured by DVOS during thigh venous occlusion differ significantly between diabetic patients with and without PAD. Our findings suggest that 60-mmHg occlusion is more effective than 100 mmHg for eliciting PAD-sensitive hemodynamic parameters. These results highlight the potential sensitivity of DVOS to PAD-related vascular impairment during low-pressure thigh occlusion.
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