Evidence map›Paper›PMID 41918159›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Phagocytosis is crucial for brain repair.

Junxuan Lyu, Wenting Zhang, Wan-Chen Wu, Rehana Leak, Jun Chen

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junxuan LyuGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.ORCID 0000-0002-1978-6213
Wenting ZhangGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2277-4686
Wan-Chen WuGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.ORCID 0009-0004-1471-5434
Rehana LeakGraduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0003-2817-7417
Jun ChenGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.ORCID 0000-0002-8077-3403

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phagocytic engulfment and digestion of extracellular material are essential for debris removal, metabolic recycling, tissue remodeling, and inflammation control after brain injury. However, the coordination of phagocytosis across cell types and disease contexts remains incompletely understood. Ju et al. demonstrate that remote ischemic conditioning enhances CD36-dependent phagocytic activity in recruited monocytes/macrophages, which contributes to improved stroke recovery. Building on these important findings, we suggest that effective brain repair requires coordinated phagocytosis across multiple cell types, extending beyond apoptotic neurons to diverse injury-associated substrates. We further argue that intracellular signaling, aging, sex, and circadian biology shape phagocytic efficiency and therapeutic potential.

Indexed as

neuroinflammationneurorestorationPhagocytosiswhite matter repair

Identifiers

PMID41918159
PMCPMC13043627

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.