Evidence map›Paper›PMID 41918165›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Taming autoimmunity: Alpha-1 antitrypsin overexpressing mesenchymal stromal cells promote regulatory T cell crosstalk to reverse diabetes.

Hua Wei, Wenyu Gou, Judong Kim, Suganya Subramanian, Tiffany Yeung, Paramita Chakraborty, Ahmed Lotfy, Shikhar Mehrotra, Stefano Berto, Charlie Strange and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hua WeiDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Wenyu GouDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Judong KimDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Suganya SubramanianDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Tiffany YeungDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Paramita ChakrabortyDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Ahmed LotfyDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Shikhar MehrotraDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Stefano BertoDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Charlie StrangeDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Hongjun WangDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA. Electronic address: wangho@musc.edu.

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7M
The Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5M
Cellular Therapy for Type 1 Diabetes using Mesenchymal Stem CellsR01DK118529 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2019 to 2025
$3.8M
Autologous BM-MSCs and Islet Co-transplantation to Enhance Islet Survival and Function in TP-IAT PatientsR01DK126454 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2021 to 2025
$3.2M
Novel Gene and Stem Cell Therapy for Type 1 DiabetesR01DK120394 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2018 to 2021
$2.2M
Alpha1 Anti-trypsin Enhances Islet Autograft SurvivalR01DK105183 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2016 to 2020
$2.0M
Sex disparities in aldosterone-dependent renal Na+ transport and blood pressure controlR01DK125464 · NIDDK · AUGUSTA UNIVERSITY · PI MAMENKO, MYKOLA · 2021 to 2025
$1.9M
BLRD VA I01 BX004536CSRD VA I01 CX002516NCI NIH HHS P30 CA138313NIDDK NIH HHS R01 DK105183NIDDK NIH HHS R01 DK118529NIDDK NIH HHS R01 DK120394NIDDK NIH HHS R01 DK125464NIDDK NIH HHS R01 DK126454NIGMS NIH HHS P20 GM148302
6 · The paper itself

Abstract

Mesenchymal stem/stromal cell (MSC) therapy holds promise as a therapeutic option in diabetes treatment. Anti-inflammatory and immunomodulatory activities are enhanced when MSCs are engineered to overexpress alpha-1 antitrypsin (AAT-MSCs). Because a single infusion of AAT-MSCs reversed new-onset diabetes in over 50% of the female non-obese diabetic mice, we used single-cell RNA sequencing, flow cytometry, and functional analyses to characterize how AAT-MSCs modulate CD4

Indexed as

alpha 1-AntitrypsinAutoimmunityMesenchymal Stem CellsT-Lymphocytes, RegulatoryAnimalsCD8-Positive T-LymphocytesCell CommunicationDisease Models, AnimalFemaleHumansIslets of LangerhansMesenchymal Stem Cell TransplantationMiceMice, Inbred NODalpha 1-AntitrypsinAATalpha -1 antitrypsin overexpressionautoimmune disease therapyCD4(+) and CD8(+) T cell modulationCD8(+) T cell exhaustionmesenchymal stem cellsMSCsNOD micenonobese diabetic micepancreatic isletregulatory T cellssingle cell-RNAseqTregstype 1 diabetes immunotherapy

Identifiers

PMID41918165
PMCPMC13213707

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.