Evidence map›Paper›PMID 41918463›Full record

ArticleChemistry & biodiversity2026

Bioactivity Profiling of Coronarin A and Villosin Isolated From Hedychium coronarium J. Koenig: Acaricidal, Nematicidal, and Antifungal Potential.

Riddhiman Lahiri, Ravendra Kumar, Sushila Arya, Alok Pratap Singh, Sakshi Negi, Shivang Joshi, Pooja Bargali, Suraj N Mali, Shilpi Rawat, Mozaniel Santana de Oliveira and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effects ofPathogens (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Riddhiman LahiriDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Ravendra KumarDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Sushila AryaDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Alok Pratap SinghBio Resource Development Department, Dabur Research & Development Centre, Dabur India Limited, Ghaziabad, Uttar Pradesh, India.
Sakshi NegiDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Shivang JoshiDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Pooja BargaliDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Suraj N MaliSchool of Pharmacy, D.Y. Patil University (Deemed to Be University), Navi Mumbai, India.
Shilpi RawatDepartment of Plant Pathology, College of Agriculture, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.
Mozaniel Santana de OliveiraLaboratory of Pharmacology of Inflammation and Behavior, Graduate Program in Pharmaceutical Sciences, Institute of Health Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0002-4076-2443
Prahlad SarkarDepartment of Agricultural Entomology, Uttarbanga Krishi Viswavidyalaya, Pundibari, West Bengal, India.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

This study explores the biocontrol potential of two labdane-type diterpenes, coronarin A and villosin, isolated from the rhizomes of Hedychium coronarium J. Koenig. The compounds were structurally characterized using FTIR, UV-Vis, HPLC, and mass spectrometry. Their bioactivities were evaluated against the red spider mite (Oligonychus coffeae), the root-knot nematode (Meloidogyne incognita), and the fungal pathogen Pestalotiopsis microspora. Coronarin A exhibited superior nematicidal activity, with 82.05% juvenile mortality and significant egg hatching inhibition at 5.0 mg/mL. Villosin demonstrated stronger acaricidal efficacy, achieving 90.28% mite mortality at the same concentration. Moderate antifungal effects were observed, particularly with villosin. Molecular docking studies revealed strong binding affinities of both compounds to acetylcholinesterase (AChE) and GABA transaminase (GABA-T), supporting their pesticidal mechanisms. ADMET analysis indicated favorable pharmacokinetic and toxicological profiles, highlighting their safety and potential for agricultural applications. This study highlights the safety and potential biopesticidal potential of the compounds, as evidenced by in vitro and in silico analyses; however, their suitability for agricultural applications will be evaluated through further field trials in future research.

Indexed as

AcaricidesAntifungal AgentsAntinematodal AgentsAcetylcholinesteraseAnimalsDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTetranychidaeTylenchoideaAcaricidesAcetylcholinesteraseAntifungal AgentsAntinematodal Agentscoronarin AHedychium coronariumMeloidogyne incognitaOligonychus coffeaePestalotiopsis microsporevillosin

Identifiers

PMID41918463
PMCPMC13040323

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.