SynthesisFrontiers in psychiatry2026
Association between maternal depressive symptoms during pregnancy and the risk of preeclampsia: a meta-analysis.
Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Depression during pregnancy is common and has been proposed as a potential risk factor for preeclampsia, but observational studies have reported inconsistent findings. This meta-analysis aimed to evaluate the association between maternal depressive symptoms during pregnancy and the subsequent risk of developing preeclampsia. Methods: PubMed, Embase, and Web of Science were systematically searched for observational studies evaluating depressive symptoms during pregnancy (measured before any assessment for preeclampsia) and reporting clinically diagnosed preeclampsia. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model accounting for the potential influence of heterogeneity. Results: Nine cohort studies involving 44,559 pregnant women, of whom 6,934 (15.6%) had depressive symptoms during pregnancy, were included. Maternal depressive symptoms was associated with a higher risk of preeclampsia (OR: 1.89; 95% CI: 1.17-3.03; Conclusions: Depressive symptoms during early pregnancy is associated with an increased risk of subsequent preeclampsia. These findings highlight the importance of screening and monitoring depressive symptoms in routine prenatal care. Systematic Review Registration: PROSPERO, identifier CRD420251250417.
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