Endocrine Society of India's National White Paper on Endocrine Disrupting Chemicals - A Call for Action.

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with hormonal pathways, leading to a broad spectrum of adverse health outcomes across the life course. This white paper by the Endocrine Society of India consolidates global and Indian evidence on EDC exposure, health effects, and regulatory challenges. Major classes of EDCs, including pesticides, industrial pollutants, plastic additives, and heavy metals, affect neurodevelopmental, reproductive, metabolic, musculoskeletal, thyroid and other outcomes, with implications extending to future generations through epigenetic and transgenerational effects. Indian data reveal widespread exposure through food, water, packaging material, and industrial waste, with studies linking EDCs to infertility, polycystic ovary syndrome, obesity and diabetes. Despite growing awareness, India lacks a comprehensive regulatory and surveillance framework for EDCs. This white paper outlines key gaps and provides actionable recommendations: strengthening systematic monitoring, harmonizing regulations, promoting research on emerging chemicals, fostering cross-sector and international collaboration, and empowering healthcare professionals and the public. Adoption of structured regulatory mechanisms modeled on global frameworks, combined with public education and institutional accountability, is essential to mitigate risk. Coordinated national efforts that bridge science, policy and community action are urgently needed to safeguard health and environment for future generations.